產(chǎn)品英文名稱：Dkk-1 Fc fusion, human
產(chǎn)品中文名稱：人重組Dkk-1 Fc fusion蛋白

Dkk-1 Fc fusion, human產(chǎn)品介紹：
DKK-1是重組人Dickkopf相關(guān)蛋白1的簡稱，是DKK蛋白家族（DKK1-4）的一員。DKK最初被認(rèn)為是非洲爪蟾蜍的前期成形細(xì)胞。通過機(jī)理研究發(fā)現(xiàn)DKK-1通過與共同受體LRP5/6一起形成抑制復(fù)合物，可以有效抑制Wnt/β-catenin信號通路。研究人員發(fā)現(xiàn)敲除DKK-1基因小鼠的腦部無法形成，從而證實Wnt/β-catenin信號通路的抑制在脊椎動物的后模式與前模式發(fā)展中必不可少。
當(dāng)DKK-1融于人IgG1蛋白的Fc片段時，這種融合避免了蛋白在體內(nèi)體外環(huán)境下的顯著失活，有效保證了其穩(wěn)定性。

Dkk-1 Fc fusion, human英文簡述：

DKK-1, Dickkopf-related protein-1, is a member of the DKK protein family which includes DKK-1 through DDK-4. DKK was originally identified as a head-forming molecule in Xenopus. Mechanistic studies showed that DKK-1 inhibits the Wnt /β-catenin signaling pathway by forming inhibitory complexes with co-receptor LRP5/6. Inhibition of Wnt/β-catenin signaling is essential for posterior patterning and anterior development in vertebrates, supported by the discovery that DKK-1 knockout mice lack head formation. When DKK-1 is fused to the Fc fragment of human IgG1. This fusion renders stability of the protein in vitro and in vivo without significant loss of activity.
StemRD expresses DKK-1 Fc fusion in human 293 cells and purifies it by protein A column.

• Purity Greater than 90% as determined by SDS-PAGE analysis
• Biological Activity The activity was determined by using a TCF reporter gene assay in cultured
human cells. The IC50 ranges from 200 - 1000 ng/ml in the inhibition of 100 ng/mL WNT-3a activity. Activity in other assays should be determined by each individual setting.
• For Research Use Only. Not for Use in Human