上皮調(diào)節(jié)蛋白是與EGFR（ErbB1）和ErbB4特異性結(jié)合但不結(jié)合ErbB2或ErbB3的EGF相關(guān)生長因子。 它主要表達(dá)于胎盤和外周血白細(xì)胞，以及膀胱，肺，腎和結(jié)腸的某些癌癥中。上皮調(diào)節(jié)蛋白刺激角質(zhì)形成細(xì)胞，肝細(xì)胞，成纖維細(xì)胞和血管平滑肌細(xì)胞的增殖。它還抑制幾種腫瘤來源的上皮細(xì)胞系的生長。

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BioGems Human Epiregulin Pre-Coated ELISA（酶聯(lián)免疫吸附測定）試劑盒是采用固相免疫測定法，專門設(shè)計(jì)用于檢測Epiregulin，96孔微板上預(yù)包被Epiregulin特異性小鼠單克隆抗體。 它含有大腸桿菌表達(dá)的重組Epiregulin。 檢測抗體是對Epiregulin特異的生物素化山羊多克隆抗體。該試劑盒已經(jīng)過分析驗(yàn)證，是即用型試劑。

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Product Details

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Components

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Reproducibility

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Description

Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines.

The BioGems Human Epiregulin Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure Epiregulin with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for Epiregulin. It contains E. coli-expressed recombinant Epiregulin. The detection antibody is a biotinylated goat polyclonal antibody specific for Epiregulin. The kit is analytically validated with ready to use reagents.