產(chǎn)品英文名稱：BMI-1 antibody (mAb)  
產(chǎn)品中文名稱：BMI-1 抗體 (mAb)

Active Motif抗體 BMI-1 抗體 (mAb)產(chǎn)品簡介：

BMI-1 antibody (mAb) Background:
BMI-1 is a member of the Polycomb PRC1 complex that is recruited to transcriptionally repressed genes subsequent to histone H3 lysine 27 methylation in order to maintain repression. In the PRC1 complex, BMI-1 is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2, resulting in the ubiquitylation of histone H2A at lysine 119.
BMI-1 acts as an oncogene and cooperates with c-myc in the initiation of lymphoma. High levels of expression of BMI-1 are observed in metastatic melanoma, and BMI-1 has been implicated in several other cancers. BMI-1 is required for hematopoietic stem cell self renewal.

BMI-1 antibody (mAb) Immunogen:
This BMI-1 antibody was raised against a recombinant protein corresponding to full-length mouse BMI-1.
 

BMI-1 抗體 (mAb)緩沖液：
純化IgG在70mMTris （pH8）中， 105 mM氯化鈉， 31 mM的甘氨酸0.07mMEDTA ，30％甘油和0.035 ％疊氮化鈉。疊氮化鈉是劇毒的。
 

BMI-1 抗體 (mAb)應(yīng)用說明：
這BMI -1抗體已經(jīng)被證實(shí)在染色質(zhì)的IP （芯片， 2-10微克每個(gè)片）的使用和免疫共沉淀（ 2-10微克每個(gè)IP ） 。詳情請參閱參考資料。
 

BMI-1 抗體 (mAb)存儲(chǔ)和保證：
在溶液中的抗體可被儲(chǔ)存在-20 ℃下2 年進(jìn)行.避免重復(fù)冷凍/解凍循環(huán)并保持在冰上當(dāng)沒有存儲(chǔ)的時(shí)候。本產(chǎn)品保證6個(gè)月自收到之日起。