產(chǎn)品英文名稱：Dkk-1 Fc fusion, human,DKKFC-050,50ug
產(chǎn)品中文名稱：人源Dkk-1蛋白Fc融合WNT信號通路抑制劑

Dkk-1 Fc fusion, human,DKKFC-050,50ug 產(chǎn)品簡介
DKK-1是重組人Dickkopf相關(guān)蛋白1的簡稱，是DKK蛋白干細(xì)胞生長分化調(diào)整因子家族（DKK1-4）的一員。DKK蛋白干細(xì)胞生長分化調(diào)整因子最初被認(rèn)為是非洲爪蟾蜍的前期成形細(xì)胞。通過機(jī)理 研究發(fā)現(xiàn)DKK-1通過與共同受體LRP5/6一起形成抑制復(fù)合物，可以有效抑制Wnt/β-catenin信號通路。研究人員發(fā)現(xiàn)敲除DKK-1基因小 鼠的腦部無法形成，從而證實(shí)Wnt/β-catenin信號通路的抑制在脊椎動物的后模式與前模式發(fā)展中必不可少。
當(dāng)DKK-1融于人IgG1蛋白的Fc片段時，這種融合避免了蛋白在體內(nèi)體外環(huán)境下的顯著失活，有效保證了其穩(wěn)定性。

人源Dkk-1蛋白Fc融合WNT信號通路抑制劑,50ug 產(chǎn)品特性
»人源Dkk-1蛋白干細(xì)胞生長分化調(diào)整因子Fc融合WNT信號通路抑制劑,50ug鑒定純度大于90%
»人源Dkk-1蛋白干細(xì)胞生長分化調(diào)整因子Fc融合WNT信號通路抑制劑,50ug生物活性在培養(yǎng)人細(xì)胞中用TCF受體基因檢測確定，拮抗劑WNT-3a 100 ng/mL時其IC50在200 - 1000 ng/ml之間

Dkk-1 Fc fusion, human,DKKFC-050,50ug 保存方法
The lyophilized protein is stable for at least one year if stored at -80 degreeC. Reconstituted protein is stable for at least four weeks at 4 degree C, but should be stored in aliquots at -80 degree C for longer term. Avoid repeated freeze and thaw.

Dkk-1 Fc fusion, human,DKKFC-050,50ug 產(chǎn)品英文描述
DKK-1, Dickkopf-related protein-1, is a member of the DKK protein family which includes DKK-1 through DDK-4. DKK was originally identified as a head-forming molecule in Xenopus. Mechanistic studies showed that DKK-1 inhibits the Wnt /β-catenin signaling pathway by forming inhibitory complexes with co-receptor LRP5/6. Inhibition of Wnt/β-catenin signaling is essential for posterior patterning and anterior development in vertebrates, supported by the discovery that DKK-1 knockout mice lack head formation. When DKK-1 is fused to the Fc fragment of human IgG1. This fusion renders stability of the protein in vitro and in vivo without significant loss of activity.
StemRD expresses Dkk-1 Fc fusion, human,DKKFC-050,50ug in human 293 cells and purifies it by protein A column.
• Dkk-1 Fc fusion, human,DKKFC-050,50ug Purity Greater than 90% as determined by SDS-PAGE analysis
• Dkk-1 Fc fusion, human,DKKFC-050,50ug Biological Activity The activity was determined by using a TCF reporter gene assay in cultured human cells. The IC50 ranges from 200 - 1000 ng/ml in the inhibition of 100 ng/mL WNT-3a activity. Activity in other assays should be determined by each individual setting.

人源Dkk-1蛋白Fc融合WNT信號通路抑制劑系列產(chǎn)品訂購信息
StemRD DKK-025  25ug  優(yōu)惠價格請來電咨詢
StemRD DKK-100  100ug  優(yōu)惠價格請來電咨詢
StemRD DKK-500  500ug  優(yōu)惠價格請來電咨詢
StemRD DKKFC-050  50ug  優(yōu)惠價格請來電咨詢
StemRD DKKFC-250  250ug  優(yōu)惠價格請來電咨詢
StemRD DKKFC-1000  1000ug  優(yōu)惠價格請來電咨詢
For research use only. Not intended for human or animal diagnostic or therapeutic uses.